Danger Signals Triggering Immune Response and Inflammation

Danger Signals Triggering Immune Response and Inflammation

Inflammation

The immune system detects "danger", through a series of what we now call damage associated molecular pattern molecules (DAMPs), working in concert with both positive and negative signals derived from other tissues. DAMPS also known as alarmins, are molecules released by stressed cells undergoing necrosis that act as endogenous danger signals to promote and exacerbate the immune and inflammatory response. DAMPs vary greatly depending on the type of cell (epithelial or mesenchymal) and injured tissue. Some endogenous danger signals are heat-shock proteins, HMGB1 (high-mobility group box 1), reactive oxygen intermediates, extracellular-matrix breakdown products such as hyaluronan fragments, neuromediators and cytokines like the interferons (IFNs).

Abdulraouf Ramadan --- Walter G. Land --- Sophie Paczesny

https://www.frontiersin.org/research-topics/4643/danger-signals-triggering-immune-response-and-inflammation

Frontiers Media SA

2017

Baihaqi

Creative Commons

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