Epigenetics of B Cells and Antibody Responses

Epigenetics of B Cells and Antibody Responses

Allergy and Immunology --- Medicine (General)

Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states.

Paolo Casali

https://www.frontiersin.org/research-topics/2508/epigenetics-of-b-cells-and-antibody-responses

Frontiers Media SA

2016

Baihaqi

Creative Commons

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English

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