Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

Medicine

Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis

Murray-Stewart, Tracy

https://www.mdpi.com/books/pdfview/book/1582

MDPI - Multidisciplinary Digital Publishing Institute

2019

Baihaqi

Creative Commons

PDF

English

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