Electronic Theses and Dissertation

Abstrak telah dilakukan penelitian tentang pengaruh ekstrak metanol daun pandan wangi (pandanus amaryllifolius roxb.) terhadap kadar kolesterol total dan trigliserida darah tikus (rattus novergicus) hiperkolesterolemia. penelitian ini bertujuan untuk mengetahui pengaruh ekstrak metanol daun pandan wangi (pandanus amaryllifolius roxb.) terhadap kadar kolesterol total dan trigliserida darah tikus (rattus novergicus) hiperkolesterolemia. penelitian menggunakan rancangan acak lengkap (ral) yang terdiri dari 5 perlakuan dan 4 ulangan. pemberian 0 ml/200g bb (p0), pemberian 4 ml/200 g bb pakan hiperkolesterolemia (p1), pemberian 4 ml/200 g bb pakan hiperkolesterolemia dan ekstrak daun pandan wangi dosis 20% (p2), 40% (p3), dan 60% (p4). ekstrak daun pandan wangi diberikan selama satu kali sehari selama 14 hari secara oral setelah 6 hari pemberian pakan hiperkolesterolemia. parameter yang diukuradalahkadarkolesterol total dankadartrigliseridadarahtikus(rattusnovergicus) jantanhiperkolesterolemia sebelum dan sesudah di berikan ekstrak daun pandan wangi (pandanus amaryllifolius roxb.). analisis data menggunakan analisis varians (anova) yang dilanjutkan dengan uji tukey. hasil penelitian menunjukkan bahwa pemberian ekstrak daun pandan wangi dapat menurunkan kadar kolesterol dan kadar trigliserida darah tikus hiperkolesterolemia. ekstrak daun pandan wangi dosis 20%, 40%, dan 60% berhasil menurunkan kadar kolesterol total dan trigliserida darah tikus. kata kunci: kolesterol, trigliserida, rattus novergicus, pandanus amaryllifoliusroxb. abstract the research on the effect of methanol extract of fragrant pandan leaf (pandanus amaryllifolius roxb.) on the levels of total cholesterol and triglyceride in hypercholesterolemia rat (rattus novergicus) blood was conducted. the objectives of this study was to determine the effect of methanol extract of fragrant pandan leaf (pandanus amaryllifolius roxb.) to the levels of total cholesterol and triglyceride in hypercholesterolemia rat (rattus novergicus) blood. the experiment used a complete randomized design consisting of 5 treatments and 4 replications by giving 0 ml/200g bw (p0), 4 ml/200 g bw hypercholesterolemia feed (p1), 4 ml/200 g bw hypercholesterolemia feed and the extract of fragrant pandan leaf dose 20% (p2), 40% (p3), and60% (p4).the fragrant pandan leaf extract was given once a day for 14 days orally after giving hypercholesterolemia feed for 6 days. the parameters measured were the levels of total cholesterol and triglyceride in hypercholesterolemia of male rat (rattusnovergicus) blood before and after giving extract of fragrant pandan leaf (pandanus amaryllifolius roxb.). the data was analyzed by using a analysis of variance(anova) followed by the tukey test. the results suggest that giving fragrant pandan leaf can lower cholesterol and triglyceride levels in hypercholesterolemia rat blood. the fragrant pandan leaf extract dose 20%, 40%, dan 60% was succesfully decreases total cholesterol and triglyceride levels in rat blood. keywords: cholesterol, triglyceride, rattus novergicus, pandanus amaryllifoliusroxb.