Electronic Theses and Dissertation

Sindrom nefrotik relaps merupakan kondisi yang sering terjadi pada anak penderita sindrom nefrotik yang ditandai dengan kekambuhan dalam 3 hari berturut-turut dalam 1 minggu setelah mengalami remisi minimal selama 1 bulan. Kekambuhan ini ditandai dengan adanya peningkatan proteinuria yang muncul kembali setelah beberapa waktu tanpa gejala. Tujuan penelitian adalah menganalisis determinan faktor risiko terjadinya sindrom nefrotik relaps pada anak di RSUDZA Banda Aceh. Jenis penelitian ini adalah analitik observasional dengan desain cross-sectional. Teknik sampling pada penelitian ini adalah total sampling (130 anak). Hasil penelitian menunjukkan bahwa dari 130 pasien anak 106 diantaranya mengalami sindrom nefrotik relaps. 72 (69,6%) berjenis kelamin laki-laki, 64 anak (60,4%) berusia 5-11 tahun, 27 anak (25,5%) bergizi tidak baik, 39 anak (36,6%) positif hematuria, 35 anak (33,0%) memiliki kadar kreatinin yang meningkat, 46 anak (43,4%) mengalami infeksi, 36 anak (34,0%) mengalami proteinuria derajat sedang, 3 anak (2,8%) memiliki hipertensi yang tidak normal. Hasil Uji analisis Chi-Square pada CI 95% dan α 0,05 menunjukkan hubungan antara proteinuria, hematuria, kadar kreatinin, hipertensi, dan infeksi (p = 0,000) dengan kejadian sindrom nefrotik relaps pada pasien anak di RSUD dr. Zainoel Abdidin Banda Aceh. Faktor risiko yang paling berhubungan dengan kejadian sindrom nefrotik relaps ialah Hipertensi dengan rasio prevalensi 5,87 yang berarti anak dengan hipertensi berisiko 5,87 kali mengalami sindrom nefrotik relaps di RSUDZA Banda Aceh.
Kata kunci: Determinan, Faktor Risiko, Sindrom Nefrotik Relaps, Anak

Nephrotic syndrome relapse is a frequently occurring condition in pediatric patients with nephrotic syndrome, characterized by relapses within 3 consecutive days in a week after experiencing minimal remission for 1 month. These relapses are marked by a reappearance of increased proteinuria after a certain period without symptoms. The research aims to analyze the determinant risk factors for the occurrence of relapsing nephrotic syndrome in children at RSUDZA Banda Aceh. This study is an observational analytic with a cross-sectional design. The sampling technique employed is total sampling, involving 130 children. The results indicate that out of the 130 pediatric patients, 106 experienced relapsing nephrotic syndrome. Among them, 72 (69.6%) were male, 64 children (60.4%) were aged 5-11 years, 27 children (25.5%) were malnourished, 39 children (36.6%) tested positive for hematuria, 35 children (33.0%) had elevated creatinine levels, 46 children (43.4%) experienced infections, 36 children (34.0%) had moderate proteinuria, and 3 children (2.8%) had abnormal hypertension. Chi-Square analysis results at a 95% confidence interval and α 0.05 indicate a significant relationship between proteinuria, hematuria, creatinine levels, hypertension, and infection (p = 0.000) with the occurrence of relapsing nephrotic syndrome in pediatric patients at RSUD dr. Zainoel Abdidin Banda Aceh. The most associated risk factor with the occurrence of relapsing nephrotic syndrome is hypertension, with a prevalence ratio of 5.87, meaning that children with hypertension are 5.87 times more likely to experience relapsing nephrotic syndrome at RSUDZA Banda Aceh. Keywords: Determinants, Risk Factors, Nephrotic Syndrome Relapse, Child