Electronic Theses and Dissertation

Hiperkolesterolemia merupakan masalah kesehatan global yang signifikan, termasuk di Indonesia, dengan prevalensinya yang tinggi menyebabkan penyakit kardiovaskular. Intervensi non-farmakologis, seperti makanan fungsional yang berasal dari buah-buahan seperti alpukat, tomat, dan nanas, memberikan efek penurunan kolesterol karena senyawa aktifnya. Penelitian ini menyelidiki efektivitas jus alpukat, tomat, dan nanas dalam mengurangi kadar kolesterol pada mencit jantan Balb/C dengan hiperkolesterolemia. Penelitian ini menggunakan desain eksperimen pretest dan posttest, 20 mencit jantan Balb/C dibagi menjadi lima kelompok: kontrol normal, kontrol positif, dan tiga kelompok intervensi dengan pemberian jus alpukat, tomat, dan nanas. Hasil penelitian ini menunjukkan bahwa setelah 7 hari intervensi jus nanas menunjukkan efektivitas tertinggi dalam menurunkan kolesterol (rata-rata penurunan = 42,50 mg/dL), diikuti oleh jus tomat (rata-rata penurunan = 41,75 mg/dL) dan jus alpukat (rata-rata penurunan = 36,50 mg/dL). Hasil uji ANOVA satu arah dan uji post hoc Games-Howell menunjukkan jus nanas paling efektif dalam menurunkan kadar kolesterol pada mencit hiperkolesterolemia.
Kata kunci: penurunan kolesterol, jus alpukat, jus tomat, jus nanas, mencit.

Hypercholesterolemia is a significant global health concern, including in Indonesia, where its high prevalence contributes to cardiovascular diseases. Functional foods derived from fruits, such as avocado, tomato, and pineapple, are known for their cholesterol-lowering properties due to their active compounds. This study aimed to evaluate the effectiveness of avocado, tomato, and pineapple juices in reducing cholesterol levels in male Balb/C mice with hypercholesterolemia. Using a pretest-posttest experimental design, 20 male Balb/C mice were divided into five groups: normal control, positive control, and three intervention groups treated with avocado, tomato, and pineapple juice. After seven days of intervention, pineapple juice showed the highest cholesterol-lowering effect (mean reduction = 42.50 mg/dL), followed by tomato juice (mean reduction = 41.75 mg/dL) and avocado juice (mean reduction = 36.50 mg/dL). Statistical analysis using one-way ANOVA and Games-Howell post hoc tests confirmed that pineapple juice was the most effective intervention for reducing cholesterol levels in hypercholesterolemic mice. Keywords: cholesterol reduction, avocado juice, tomato juice, pineapple juice, mice.