Electronic Theses and Dissertation
Universitas Syiah Kuala
SKRIPSI
PERBANDINGAN EFEKTIVITAS ANTARA TERAPI KOMBINASI ONDANSETRON-DEKSAMETASON DENGAN GRANISETRONDEKSAMETASON TERHADAP MUAL MUNTAH AKUT AKIBAT KEMOTERAPI REGIMEN TAC PADA PASIEN KANKER PAYUDARA
Pengarang
Cut Mela Yunita Sari - Personal Name;
Dosen Pembimbing
Nomor Pokok Mahasiswa
1107601020011
Fakultas & Prodi
Fakultas Kedokteran / Ilmu Penyakit Dalam / PDDIKTI : 11702
Subject
Kata Kunci
Penerbit
Banda Aceh : Fakultas Kedokteran., 2013
Bahasa
Indonesia
No Classification
615.58
Literature Searching Service
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“Comparison of the effectiveness of the combination therapy of ondansetrone-dexamethasone
to granisetrone-dexamethasone in the preventing of acute nausea - vomiting due to TAC
regimen of chemotherapy in breast cancer patients”
Cut Mela Yunita Sari, M. Riswan, Fauzi Yusuf
Division of Medical Hematology and Oncology, Departement of Internal Medicine
Faculty of Medicine, University of Syiah Kuala / Dr. Zainoel Abidin General Hospital Banda AcehIndonesia
Background.
The American Cancer Society estimates that in 2013 , there were 14 % of all cancer deaths caused
by breast cancer . TAC regimen of chemotherapy is one of treatment modality of breast cancer , and
has a high emetic potential. Ondansetron and granisetron plays an important role in the prevention of
acute nausea and vomiting due to chemotherapy. Ondansetron as an effective single dose in 32mg
doses, while effective at a dose of 1mg granisetron.
Purpose.
To obtain a comparison between the effectiveness of the combination therapy of ondansetronedexamethasone to granisetrone – dexamethasone in the preventing of acute nausea - vomiting due to
TAC regimen of chemotherapy in breast cancer patients.
Patients and Methods.
This study is a clinical trial with single-blind and cross-over design , the first group received
ondansetron 32mg and dexamethasone 20mg on the first cycle and then got granisetron 1mg and
dexamethasone 20 mg on the second cycle or vice versa in the second group . This research was
conducted at Dr.Zainoel Abidin’s Hospital from June to August 2013 . All subjects performed an
assessment of the quality of nausea , vomiting frequency , therapeutic response and side effects
within the first 24 hours of chemotherapy.
Results.
There was no significant difference in the degree of nausea , vomiting and frequency response
between combination therapy with ondansetrone – dexamethasone to granisetrone- dexamethasone
in the prevention of acute nausea and vomiting due to TAC regimen. The most common side effects
reported were decreased appetite, headache, abdominal discomfort, insomnia and impaired vision.
Side effects more visual disturbances reported in ondansetron group, p = 0.02.
Conclusion.
Granisetron - dexamethasone combination therapy has the same effectiveness with ondansetron -dexamethasone , both well tolerated , although side effects were reported more visual impairment in
the ondansetron group.
Keywords :
Antiemetics, breast cancer, chemotherapy, dexamethasone, graniisetrone, ondansetrone,
TAC regimen,
Tidak Tersedia Deskripsi
PROPORSI MUAL DAN MUNTAH AKUT DAN TERTUNDA YANG DIINDUKSI KEMOTERAPI DENGAN REJIMEN TAXOTERE ADRIAMYCIN CYCLOPHOSPHAMIDE(TAC) PADA PENDERITA KANKER PAYUDARA DI RUANG MAMPLAM III BLUD RSUD DR. ZAINOEL ABIDIN BANDA ACEH (VIVI ROSANDI, 2016)
GAMBARAN JUMLAH NEUTROFIL SEBELUM DAN SESUDAH KEMOTERAPI BERDASARKAN JENIS REGIMEN KEMOTERAPI PADA PASIEN KANKER DI RUMAH SAKIT UMUM DAERAH DR. ZAINOEL ABIDIN BANDA ACEH (M HABIBIE RUNANDA, 2019)
PERBANDINGAN EFEKTIVITAS ANTARA TERAPI KOMBINASI ONDANSETRON-DEKSAMETASON DENGAN GRANISETRONDEKSAMETASON TERHADAP MUAL MUNTAH AKUT AKIBAT KEMOTERAPI REGIMEN TAC PADA PASIEN KANKER PAYUDARA (Cut Mela Yunita Sari, 2014)
PERBEDAAN KUALITAS TIDUR SEBELUM DAN SESUDAH KEMOTERAPI SIKLUS I PADA PASIEN KANKER PAYUDARA DI RSUD DR. ZAINOEL ABIDIN BANDA ACEH (Nadya Izzaty Away, 2017)
GAMBARAN EFEK SAMPING KEMOTERAPI BERBASIS ANTRASIKLIN PADA PASIEN KANKER PAYUDARA DI RUMAH SAKIT UMUM DAERAH DR. ZAINOEL ABIDIN BANDA ACEH (SARAH NABILA, 2015)