Electronic Theses and Dissertation

Penelitian ini bertujuan mengetahui efektivitas ekstrak kulit buah pisang kepok (M. acuminata Linn.) terhadap penurunan kadar glukosa darah pada mencit (Mus musculus L.) yang diinduksi aloksan. Metode yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap (RAL) yang terdiri dari 5 perlakuan dan 5 ulangan. Hewan uji yang digunakan ialah 25 individu mencit jantan yang diinduksi aloksan sebanyak 50 mg/kgBB pada hari ke-0, kecuali kontrol negatif (K-). Hari ke 3 hewan uji mendapat perlakuan pemberian akuades pada kontrol negatif (K-), Glibenklamid sebanyak 0,65 mg/kgBB pada kontrol positif (K+), ekstrak kulit buah pisang kepok dosis 100 mg/kgBB (P1), dosis 200 mg/kgBB (P2), dan dosis 400 mg/kgBB (P3) selama 14 hari. Pemeriksaan kadar glukosa darah dilakukan pada hari ke 0, 3, dan 15. Data dianalisis menggunakan ANAVA taraf signifikan 5% dengan uji Duncan sebagai uji lanjut. Hasil penelitian pemberian ekstrak etanol kulit buah pisang kepok menunjukkan bahwa terdapat pengaruh nyata (P

This study aimed to investigate antidiabetic potential of ethanol extract of kepok banana (Musa acuminata Linn.) peel on blood glucose levels. The method used in this study was a completely randomized design (CRD) consisting of 5 treatment groups and 5 replications. Twenty-five male mice were randomly divided into 6 treatment groups with 4 replications: healthy mice (normal control, K-), diabetic mice treated with kepok banana (Musa acuminata Linn.) peelextract of 100 (P1), 200 (P2), and 400 mg/kg BW (P3), and rats which were induced by 0,65 mg/kg BW of Glibenclamide (positive control, K+). Diabetic condition was achieved by a single injection of alloxan 50 mg/kg BW. Treatments were given once a day for 14 days. On day 0, 3 and 15 blood samples were withdrawn from mice for glucose measurement. Data was analyzed by ANOVA and followed by Duncan test. The results showed that kepok banana peel extracts significantly (p